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Dual PI3K/mTOR inhibitor PKI-402 suppresses the growth of ovarian cancer cells by degradation of Mcl-1 through autophagy

A likely explanation is that the BAs bound to a sequestrant into the intestinal lumen can't be absorbed and hence travel more distally in the GI tract where the complexes are still capable to activate the TGR5 expressing colonic L-cells

Know when to take the medication

If you are pregnant or planning to be, it can also affect your treatment plan

Heart rate monitoring during the initial titration phase provides useful safety data