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In rodent models, it promotes lipolysis by converting stored fat into free fatty acids without stimulating GH pathways, including IGF-1

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A 2016 trial funded by Novo Nordisk on semaglutide and cardiovascular outcomes in type 2 diabetes patients revealed more gastrointestinal disorders in the semaglutide group compared to the placebo group

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Contact your GP if vomiting persists beyond 2448 hours or prevents fluid intake, as dose adjustment or supportive treatment may help