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Limitations of Evidence Limitations of Evidence Animal-dominant data: Most findings are from rodent and cell models

Unlike metformin, which interferes with calcium-dependent B12 absorption in the ileum, GLP-1 receptor agonists do not have a known mechanism that would directly impair B12 absorption or metabolism

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However, because the FDA has not approved this treatment for skin whitening , it is crucial to consider potential side effects before choosing it

Overall, there is not sufficient evidence to recommend B12 on its own for the elderly with impaired cognitive function, although those with early symptoms may benefit