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Otherwise, the oxidized vitamins will become new toxins and accumulate in body, then forming new free radicals

For instance, protein disulfide isomerase (PDI) deficiency, which induces misfolding stress in the ER, has been linked to disruptions in focal adhesions and cytoskeleton organization, particularly through the downregulation of MSN and CNN3 [70] both of which were observed to be downregulated in our proteomic analysis

Claudia von Boeselager [00:32:27]: Yeah, there's no point

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The essential role of ThDP in mitochondrial energy production (Figure 1) is universal for all tissues and therefore can hardly explain specific and primary vulnerability of the gastrointestinal system