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Similarly, NEK7 is glutathionylated at Cys253 and requires GSTO1-dependent deSSG to interact efficiently with NLRP3 67

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Nonetheless, even though an IN chelator enters the brain, its distribution is unlikely to be region-selective, which is a major limitation

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Both SLC7A11 knockdown or overexpression can induce ferroptosis in hepatocytes of MAFLD model mice, but the mechanisms are different