Upon cellular fractionation, mutants exhibited a significant decrease in tGSH and GSH in the cytosolic fraction compared to controls, where most cellular GSH is located (Extended Data Fig
1c, d) 42,58 , a rather unspecific GSH-dependent monothiol mechanism might be better suited for the reduction of a variety of physiological non-glutathione disulfide substrates to maintain metabolites and proteins in a reduced state (Fig
P450 enzymes are involved in the metabolism of a wide range of compounds, including drugs, steroid hormones, fatty acids, and bile acids
Total reduction in spot ultraviolet, spot polarization, and skin tone were measured and recorded using a Janus Facial Analysis System (PIE Co., Ltd, Suwon-si, Gyeonggi-do, Korea)
These Cl transport defects leading to loss the concentrating capacity of the nephron as well as to reduced Na + reabsorption in the more distal regions of the nephron
By wrapping the glutathione in this protective fatty layer, we can shield it from the harsh environment of the digestive tract