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PMID: 26014291

Reactive oxygen species and their physiological actions Reactive oxygen species are generated during crucial processes of oxygen (O 2 ) consumption [11]

25,26 Furthermore, a polymorphism of the DHFR enzyme resulting in a 19bp deletion within the site of a key regulatory sequence has been theorized to exhibit negative effects on the expression and activity of this enzyme

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Insulin-like growth factor-1 and 2 Renal IGF-1 not only derives from the circulation (mainly synthesized in the liver) but is also locally produced in the kidney [15]