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Joseph Rizzo, senior author of the July 2024 study that found an association between semaglutide and NAION, called the condition, in effect, a stroke of the optic nerve. Rizzo is the director of neuro-ophthalmology at Mass Eye and Ear in Boston
Glucagon traditionally raises blood sugar, which seems counterproductive for a weight loss medication
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Other Emerging Therapeutic Targets Amylin Mimetics Amylin is a neuroendocrine peptide co-secreted by pancreatic -cells postprandially with insulin and acts to inhibit glucagon secretion, reduce gastric emptying and centrally induce satiety [76]
However, preclinical safety studies report no major toxicity across animal studies (mice, rats, rabbits, dogs) and showed no adverse effects across several organ systems
Previously discussed reports suggest that DPP4i may be more effective in the Asian population than in the white population [78,79]
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