Preclinical studies report approximately 1.6 increases in intracellular NAD+ following NNMT inhibition in adipocyte models
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Wu J, Yu X, Xue K, Wu J, Wang R, Xie X, Li K, Yang Z, Yue J (2020) The Inhibition of miR-873 Provides Therapeutic Benefit in a Lipopolysaccharide-Induced Neuroinflammatory Model of Parkinsons Disease
In a study on 63 patients with PWS, it was demonstrated that a balanced energy-restricted diet of approximately 30% fat, 45% carbohydrates (at least 20 g of fiber/day), and 25% protein significantly improved body weight composition in patients with PWS compared to a standard energy-restricted diet [85]