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Gene ontology and pathway analysis revealed that 26% of CR responded DEGs are involved in malignancy and cancerassociated networks The 26% (121/467) of DEGs were characterized in IPA (Supplementary Table S5)

Foxo forkhead transcription factors induce G(2)-m checkpoint in response to oxidative stress

Kang R, Kroemer G, Tang D

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These pleiotropic actions are mediated through a complex network of interconnected molecular pathways, underscoring SFNs value as a multi-targeted agent in oncology and providing a mechanistic basis for its synergy with conventional therapies