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Cholestyramine Targeting Altered Bowel Habits Twenty-five to 50% of the patients with IBS-D show signs of excess bile acids entering the colon or bile acid malabsorption (BAM) ( Good candidates for cholestyramine (second-line) Mild to severe IBS-D patients with BAM or patients with diarrhea as predominant symptom (after loperamide failure or worsening of the symptoms after cholecystectomy)

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