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Epigenetic Reprogramming: Making Neurodegeneration Reversible Sinclair's most consequential claim concerns OSK therapy Oct4, Sox2, and Klf4, three Yamanaka factors delivered in a partial reprogramming formulation called ER100

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One of the targets of GSK3, relative to translation, is eIF2B

The gap between regulatory approval and clinical interest is an important discussion point in emerging therapies

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