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J Clin Endocrinol Metab 86:37173723 Nauck M, Stckmann F, Ebert R, Creutzfeldt W (1986) Reduced incretin effect in type 2 (non-insulin-dependent) diabetes

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Some patients report improved mood and reduced food-related anxiety, while others experience initial jitteriness or emotional blunting during dose escalation

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For participants receiving twice-daily IR-Tac, blood samples were collected at 0 (predose) and 0.5, 1, 1.5, 2, 3, 4, 6, 8, 12, 12.5, 13, 13.5, 14, 15, 16, 20, and 24 hours postdose