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We specifically explore how genomic testing may be used in three primary radiotherapy applications for BM: patient stratification, early radiation treatment response monitoring, and selection of systemic therapies for use in combination with radiotherapy

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The combined action of these events results in an increased local availability of free serum IGF-I, which is then transported by transcytosis using an endothelial transporter (lipoprotein related receptor 1) dependent mechanism[67]

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For example, muscle, which belongs to the musculoskeletal system, is also an endocrine organ, producing and releasing signaling molecules (myokines) into the bloodstream in response to muscle contractions and exercise