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FDA-approved uses Wegovy is FDA-approved for chronic weight management in patients with obesity (body mass index 30 kg/m or greater) and overweight (body mass index 27 kg/m or greater) with at least one weight-related condition such as high blood pressure (hypertension), type 2 diabetes, high cholesterol levels, and heart disease, when used as an adjunct to a healthy lifestyle, reduced-calorie diet, and exercise

Less tropic hormone secretion leads to less stimulation of cortisol secretion by cells in the adrenal cortex

Mild injection-site irritation

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Other factors that increase risk include gallbladder disease, very high triglyceride levels, and heavy alcohol use