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Under normoxic conditions, Nrf2 binds to Keap1 and continues to be inactivated by ubiquitination and degradation in the proteasome (Lu et al., 2017)

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The antiangiogenic activity of melatonin also occurs through a series of indirect mechanisms

Ex vivo bronchial biopsies derived from asthma patients and human lung fibroblasts culture in vitro demonstrated apigenin (10, 20 M) attenuates TGF- induced fibroblast-to-myofibroblast transition, in a non-cytotoxic and non-cytostatic manner, potentially correlated with the inhibition of -smooth muscle actin and tenascin C expression [141]

Detoxification: Enhances clearance of toxins, heavy metals, and free radicals

23 , e13435 (2022)