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The glutathione peptide of one inhibitor, termed productive binding, occupies the G-subsite with multiple interactions similar to those observed for other glutathione S-transferases, while the glutathione backbone of the second inhibitor, termed unproductive binding, exhibits only weak interactions mediated by two polar contacts

10.3389/fnhum.2014.00537 47 HuB.SunS

I.DeLucaJ.IsaacsS.BaggishA.WeinerR.et al (2015)

It stimulates GnRH release, which drives LH and FSH the pituitary hormones governing ovulation and cycle regularity

They can cause significant discomfort and lead to severe complications if not treated promptly