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For lupus patients, this connection carries particular significance

10.2147/ott.s167422 65 NascimentoM

Furthermore, since estrogen receptors are ubiquitously located, estrogen-mediated signals modulate the biology of several tissues and organs, including the central nervous system

Significant nausea or vomiting may occur during the dose-escalation phase

These are not typical reactions and must be evaluated by a medical professional right away