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For example, senescent T-cells are accumulated in visceral adipose tissues in obesity 67 and produce proinflammatory cytokines, leading to chronic inflammation, metabolic disorders, and cardiovascular diseases 68,69

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Indeed, lipidomics revealed that nearly all the significantly depleted lipid species in serum from Gclc KO mice were triglycerides (Fig

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[14] [15] In those studies, the lowest dose (600 mg) tended to be as well-tolerated as placebo, with no significant difference in adverse events compared to placebo