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Gastroprotective nutrients include: Zinc-Carnosine

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Studies show that patients who follow standardized injection protocols experience more consistent appetite suppression and predictable dose responses compared to those with variable technique

The upregulation of genes such as Zif268 has been proposed as part of the underlying mechanism

Nevertheless, since peripheral ghrelin can cross the BBB (Banks et al., 2003), GHS-R1a likely exerts its effect on brain function even with inadequate production of central ghrelin

10 Conclusions and future perspectives In conclusion, studying the mechanisms of comorbidity through the perspective of ferroptosis is essential, with GPX4 and Nrf2 being highlighted as critical targets