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L-carnitine supplementation improves serum lipid parametersincluding total cholesterol (TC), triglycerides (TG), and low-density lipoprotein (LDL) in NASH patients ( ) intervention for 6 months significantly decreased controlled attenuation parameter (CAP) values in NAFLD patients, indicating reduced hepatic steatosis ( Molecular regulation of fatty acid -oxidation extends beyond core enzymatic machinery (CPT1, CPT2) to include sophisticated transcriptional and post-translational control mechanisms involving AMP-activated protein kinase (AMPK), peroxisome proliferator-activated receptor (PPAR), and peroxisome proliferator-activated receptor coactivator-1 (PGC1) (44)

G., Stein-Hammer, C

Other mechanisms of acetylcarnitine action Acetylcarnitine has been suggested to protect against oxidative stress through the induction of antioxidant genes and an increase in HO-1 (heme oxygenase 1) expression in vitro and in vivo [17, 18]

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