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Adults over 50 face similar concerns, as age-related bone loss is already underway and the ability to rebuild lost bone becomes progressively more limited

In a genetic preclinical study, embryonic GIPR knockout mice fed a high-fat diet were protected from obesity, supporting the role of GIPR antagonism as a method to promote weight loss and prevent weight gain (67)

Designed ankyrin repeat proteins (DARPins): Binding proteins for research, diagnostics, and therapy

Semaglutide GLP-1 is a medication that acts as a glucagon-like peptide-1 (GLP-1) receptor agonist

(eClinicalMedicine) found that 52 weeks of once-weekly semaglutide reduced hip bone mineral density by 2.6% and lumbar spine density by 2.1% compared to placebo, with increased bone resorption and no compensatory increase in bone formation

& Schafer, A