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Interestingly, PNPLA3 I148M is not properly targeted by the UPS which likely promotes the disease-causing variant to accumulate on LDs (135) where it can disrupt protein-protein interactions critical for TAG hydrolysis (70, 75)

IP-1 - intervening peptide 1

It puts severe renal impairment, gastroparesis, recent bariatric surgery, and pregnancy or breastfeeding in the relative category

It is one of the most-studied compounds in dermatology and matrix-biology research literature, frequently referenced in pre-clinical models of extracellular-matrix remodelling and gene-expression studies

Notably, a diet rich in dietary fiber and whole grains is associated with a decreased incidence of F

In case of an allergic response, consult a healthcare professional immediately