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Nausea (41%), diarrhea (23%), vomiting (20%), and constipation (18%) are the most frequently reported

Over 68 weeks, semaglutide 2.4 mg produced 14.9% mean body weight reduction versus 2.4% with placebo

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References: Office of Dietary Supplements, NIH

Your arm may feel heavy, itchy or slightly bruised at the injection site but these side effects generally pass quickly