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Psychopharmacology (Berl) 2006;184:2546

Other lipid targets for high performance: HDL above 60 mg/dL, total cholesterol/HDL ratio below 3.5

323,324 In cardiovascular diseases such as hypertension and HF, vascular dysfunction contributes not only to abnormal blood pressure regulation but also to increased cardiac afterload, impaired tissue perfusion, and progressive end-organ damage

This can lead to a decrease in the effectiveness of drugs and an unexpected treatment outcome

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