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Should I inject locally or systemically

*Correspondence: Jing Yao, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Given these essential functions, serum copper levels are closely associated with cardiometabolic risk factors, including dyslipidemia, type 2 diabetes, and obesity, and are regarded as predictive indicators of cardiovascular disease risk [29]

Upon ligand binding, TLRs recruit adaptor proteins primarily MyD88 or TRIF which activate downstream kinases including IRAKs and TRAF6, leading to the stimulation of transcription factors NF-B, AP-1, and IRF family members [33]

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