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Given that glandular secretion in response to SubP is defective in CF, a speculation is that SubP-mediated secretion in CF might be associated with enhanced muc5AC to muc5B secretion ratios, effectively mimicking asthma [98]

Most people tolerate B12 injections very well, and side effects are usually mild and short-lived

This leads to dose-dependent weight loss (typically 8-15% in monotherapy trials), with additive effects when combined with GLP-1 agonists like semaglutide due to complementary mechanisms on energy balance and gastrointestinal function

Add fecal calprotectin if gut health is your goal, and P1NP if you're tracking tissue repair

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The recommended minimum during GLP-1 therapy is 0.8-1.2 grams of protein per kilogram of body weight