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Adult mice with a deletion of MDM4, an MDM2 homolog and a negative regulator of p53, exhibited dilated cardiomyopathy

Enhancing vascular health by modulating IGF- 1 signaling could represent a potential therapeutic strategy to counteract age-related muscle decline

Novel mitochondrial complex I-inhibiting peptides restrain NADH dehydrogenase activity

doi: 10.5534/wjmh.220067 113 ChandraAKSenguptaPGoswamiHSarkarM

They recommend ongoing surveillance as with any medication, but they havent found evidence of increased risk