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This buildup is thought to trigger downstream effects, including the formation of tau-containing neurofibrillary tangles, due to an imbalance between A production and clearance

The short plasma half life of dihexa is a feature, not a limitation: it allows precise temporal control over receptor activation without accumulation toxicity, making it one of the most pharmacologically elegant cognitive enhancers in contemporary neuroscience research

The results revealed that the levels of pro-inflammatory cytokines IL-6, IL-12, and TNF- secreted by cells treated with NP4 were 1.45, 5, and 1.78 times higher than those secreted by cells treated with NP2, respectively, further confirming the activation of macrophages

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10.1007/s00253-019-09698-y 198 MiW.MengM.XuF.SunL