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25 , 11471159.e10 (2017)

The expression of pro-inflammatory mediators, including interleukin-1 (IL-1), IL-6, and tumor necrosis factor (TNF-), increase in cartilage, bone, and synovium, contributing to the initiation of OA 4,5

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By Month 4, as the body fully adjusts to the medication and metabolic adaptation occurs, up to 95% of patients report resolution