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Individual Factors Influencing Optimal Glutathione Dosage Baseline glutathione levels, antioxidant enzyme capacity, age, and genetic variations in phase II detoxification genes influence how much glutathione an individual can metabolize effectively
However, in response to oxidative stress, GPX7 can promote stress signal transduction and release through interaction with corresponding targeted proteins
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Nat Commun 16 , 10479 (2025)
Where a claim relies on inference from the broader literature, we say so
Notably, similar inhibitions were observed both with the wild type enzyme and its cysteine mutants, suggesting that thiol conjugation is dispensable for GST inactivation by auronofin in contrast to other described targets 103
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