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Although TFBUT was the primary clinical endpoint, the study was powered on TNF- as a biologically relevant surrogate due to limited prior ophthalmic data for GSH-C4

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Hepatic and Metabolic Benefits A MAFLD/MASLD (metabolic dysfunction-associated steatotic liver disease) sub-study of the Phase 2 obesity trial reported that over 85% of participants on the highest retatrutide doses achieved more than 30% reduction in liver fat content measured by MRI, with many reaching complete resolution of steatosis

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After cystine is absorbed by system xc, it will be reduced to cysteine to synthesize GSH, which maintains the activity of GPX4 [8, 9]

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