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Generally, damage to the outer and middle ear causes conductive hearing loss, whereas inner ear damage results in sensorineural hearing loss (Medwetsky 2007)

Defects in both UPR signaling and ERAD have been strongly implicated in neurodegenerative diseases, including Alzheimers disease and amyotrophic lateral sclerosis (ALS), highlighting the clinical relevance of maintaining proper ER zinc homeostasis 126,127,128

Multiple sclerosis and cancer incidence: a Danish nationwide cohort study

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