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doi: 10.1016/j.biopha.2017.09.097 74

Clinical trial averages: Wegovy (semaglutide): ~15% of body weight Zepbound (tirzepatide): ~20% of body weight Some people lose considerably more

In conclusion, while GLP-1RAs and GLP-1/GIP dual agonists offer significant clinical advantages, ongoing research and vigilant monitoring of their adverse effects and safety are essential for optimizing their therapeutic application