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Combined administration produced a GH excursion larger than either compound singly in healthy adult preparations

"Bupropion Inhibits Serotonin Type 3AB Heteromeric Channels at Clinically Relevant Concentrations"

LCLs derived from 60 Caucasian-American (CA), 56 African-American (AA), and 60 Han Chinese-American (HCA) healthy subjects were obtained from the Coriell Cell Repository (Camden, NJ) (sample sets HD100CAU, HD100AA, and HD100CHI)

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These methods allowed a highly accurate assessment of the impact of the timing of small intestinal exposure to metformin on the subsequent glycaemic, insulinaemic and GLP-1 responses