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Published research of our programme in JMIR Formative Research reports an average weight loss of 19.1% at 12 months with semaglutide and behavioural support

Consistent with this, Insl5 increases food intake in a dose-dependent manner in nonfasted control mice, but these effects are not preserved in relaxin/insulin-like family peptide receptor 4 knockout mice, receptors expressed on enteric and vagal afferent neurons but not in the hypothalamus 235

In particular, incomplete retrieval of grey literature and insufficient documentation of study-exclusion decisions could lead to overestimation of benefits or underdetection of harms, while the infrequent propagation of primary-study bias into meta-analytic models reduces confidence in the magnitude of pooled effects

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The neurological effects of Pernicious Anaemia are complex, and recovery is rarely straightforward

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