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Rogozhin, Institute of Bioorganic Chemistry (RAS), Russia Luminita Marutescu, University of Bucharest, Romania Updates Copyright 2025 Sceglovs, Skadins, Chitto, Kroica and Salma-Ancane

The Era of Small-Molecule GLP-1 Drugs Is Emerging The approval of Orforglipron represents more than the launch of a new drugit reflects a major shift in oral GLP-1 drug development trends toward small-molecule innovation

Liposomal delivery is much gentler, as the nutrient is encapsulated

The common co-morbidity with obesity, diabetes, and metabolic syndrome makes it almost impossible to distinguish the pathophysiology (100)

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This step is a prerequisite to enhance the affordability of these medications, particularly for socioeconomically disadvantaged people