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The one human trial that will measure tolerability directly has not started reporting it is only recruiting (planned 2026), studies a topical gel on small standardized wounds , and lists safety as a secondary, not primary, outcome (NCT07437586)

The tumour-associated glycoprotein podoplanin is expressed in fibroblast-like synoviocytes of the hyperplastic synovial lining layer in rheumatoid arthritis

Nutrition 20:696703

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Platelet-rich plasma therapy concentrates growth factors from your own blood and injects them to stimulate healing

This would also enable prescribers to lawfully prescribe these substances consistent with their prescribing authority under applicable state law and the broad discretion afforded to physicians under the practice of medicine