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Postmenopausal women lost about 35% more weight when using menopausal hormone therapy alongside tirzepatide a GLP-1-based, Food and Drug Administration-approved drug for the overweight and obese compared to those taking the drug alone, according to a Mayo Clinic study

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[9] In general, any patient with nutritional deficiencies, liver disease, or other serious comorbidities should use ALA only under a physicians guidance, with appropriate monitoring

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(2016) 55:e1416

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Post-treatment, the expression of the serotonin reuptake transporter (SERT) significantly increased, while tryptophan hydroxylase-1 (TPH-1) expression significantly decreased in colonic tissue, suggesting exendin-4 mitigates visceral hypersensitivity by upregulating SERT and downregulating TPH-1

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