L-Arginine Has Shown Many Gastrointestinal Side Effects While L-arginine has been widely studied for its role in nitric oxide production and its potential to enhance workout performance, for the same reasons it doesnt absorb as well as L-citrulline, it has comes with gastrointestinal side effects
Phylum-level analysis (Figure S1D) revealed that the VPA-ASD group was dominated by Pseudomonadota (Proteobacteria), with elevated Deferribacterota and Campylobacterota, and severe depletion of Bacteroidota and Verrucomicrobiota

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This hypothesis is supported by emerging data but has not been definitively confirmed in large trials
That's where the "Ozempic-adjacent" framing comes from
Why do people explore glutathione therapy