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443 Unfortunately, the trial results showed that CSL112 did not significantly reduce the composite primary endpoint, challenging the longstanding hypothesis that direct enhancement of HDL function would provide clinical benefits

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In contrast, another study found that late stage of differentiation exposure at 300 nmol/l led to upregulation of lipolytic adipose triglyceride lipase (ATGL), aligning with the known lipolytic effects of GLP-1-RAs in human adipocytes

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