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453 Emerging evidence indicates that exogenous stimuli, including fungal components, may drive and perpetuate immunosenescence

In one trial, 16 people placed on experimental bed rest for 3 weeks (in order to increase urinary calcium excretion by causing bone breakdown) and treated with 20 mg per day of the bisphosphonate alendronate had lower urine calcium concentrations, and lower calcium oxalate and calcium phosphate saturations, compared with placebo (Ruml 1995)

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Nutritional information Serving size: 30 ml (1/2 shot) **Reference intake for an adult

Biochem Biophys Res Commun 1976;71:9528