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Physical Activity Guidelines recommend at least 150-300 minutes of moderate-intensity aerobic activity weekly, plus muscle-strengthening activities at least twice weekly

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Its dramatic age-related decline is significant: plasma concentrations average 200 ng/mL at age 20 but typically plummet to 80 ng/mL by age 60a 60% reduction correlating with visible aging and reduced healing capacity

Its deep restorative properties are effective in relieving pain caused by inflammation, providing rapid soothing and restorative results

In pregnancy, it helps protect both the mother and foetus from potential complications, such as birth defects and pregnancy-related issues

However, effective therapies in preclinical models have not translated into clinical trials and we have no universally accepted disease-modifying treatments