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doi:10.1016/j.psc.2017.07.001 Moriyama TS, Polanczyk G, Caye A, Banaschewski T, Brandeis D, Rohde LA

In contrast, a synbiotic (like Seed DS-01) works over time to shape the gut microbiome and support overall digestive function

Before reconstitution: Store at -20C, protected from light and moisture

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This timeline matches B12 pharmacokinetics: intramuscular methylcobalamin reaches peak serum concentration at 8-12 hours, but tissue saturation (particularly in the liver and nervous system) occurs over 48-72 hours as the vitamin is transported into cells and converted to active coenzyme forms (Andrs et al., 2018)

To this end, the researchers tested the physical and cognitive performance of middle-aged mice, choosing this age to capture the early stages of age-related decline