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Administering hepsin to wild-type mice increases APAP tolerance and downregulates GJ expression Considering the potential clinical and medical applications, we evaluated a therapeutic strategy involving the administration of hepsin to wild-type adult mice and assessed its potential to mitigate APAP-induced liver injury

Oxidative stress is involved in a variety of neurodegenerative diseases, such as Alzheimers disease (AD), Huntingtons, and Parkinsons diseases [107109], and neurodevelopmental disorders, including ASD [28, 110, 111]

FIGURE 2 7 Ferroptosis and cardiovascular disease co-depression We have previously discussed the separate roles of iron death in AS and depression

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