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Metformin is an FDA-approved medication with extensive clinical outcome and safety data, while berberine is a dietary supplement with variable formulations, lower bioavailability, and less consistent research quality. Berberine may help shift the body toward better glucose and lipid metabolism, but it is not a magic weight-loss supplement and not a substitute for medical treatment and/or intervention, Katz advises

It is possible that we obtain data from you through external service providers or public sources

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Contrariwise, in the study by Jensterle et al

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Intrahepatic cholestasis most often occurs in diseases involving hepatocellular damage, leakage, or swelling, such as infections (e.g., bacterial cholangiohepatitis, toxoplasmosis, FIP, or other diseases causing inflammation), infiltrative diseases (e.g., lymphoma), metabolic diseases (e.g., hepatic lipidosis), or diseases causing disruption of architecture (e.g., cirrhosis or severe polycystic disease)