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Research suggests that metformin can reduce vitamin B12 absorption in the digestive tract, potentially leading to lower B12 levels over time

Comprehensive computational exome sequencing analysis also revealed a number of genes, six of which ( SETD1A , CUL1 , XPO7 , GRIA3 , GRIN2A , and RB1CC1 ) had odds ratios higher than ten, with their rare mutations markedly increasing the risk for schizophrenia (Nakamura and Takata, 2023)