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however, the clinical significance and durability of these effects remain under investigation

This is a conundrum that, I believe, can only be resolved by randomly assigning a large group of participants to either taking the supplement or taking a placebo, following them for years, and comparing them

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it is not FDA-approved and not for human consumption

Because birds lack 12- and 15-desaturases, both n-6 and -3 PUFAs must be supplied through the diet, and the endogenous conversion of ALA to EPA/DHA is inherently limited, with desaturation at the 6 position representing a major metabolic bottleneck (44)

Lower risk of desensitization: Alternating mechanisms prevent receptor fatigue or feedback inhibition