Many GLP-1 users find that bloating improves significantly after the first 4 to 6 weeks on their medication
Dubbed the "triple G" drug, retatrutide targets GLP-1, GIP and glucagon rather than just one or two of those hormones like existing treatments
However, in patients with obesity, insulin resistance, and type 2 diabetes, skeletal muscle mitochondrial oxidative capacity is universally compromised, manifesting as reduced mitochondrial density and decreased respiratory chain complex activity ( Figure 4 )
XuXTangQGaoYChenSYuYQianHet al
doi: 10.1172/jci.insight.175479 150 SakaiOUchidaTImaiHUetaT
Patients should be advised to maintain adequate hydration and seek urgent medical attention if they notice markedly reduced urine output or dark, concentrated urine