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In addition to monotherapy, numerous studies indicate that combination therapy may improve clinical symptoms in patients with DPN [95,96,110,146,218,219,220,221]

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203 In a clinical trial involving 26 men, treatment with an antioxidant cocktail containing both vitamins C and E, as well as coenzyme Q10, was associated with significant improvements in measures of respiratory function in patients with obstructive sleep apnea

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This decision is rarely taken lightly and often arises after months or years of being told that treatment cannot proceed until a BMI threshold is met